Norco vs Oxycodone: Similarities & Differences

Norco vs Oxycodone

The availability of remedial alternatives with the advancement sometimes gives us a headache to compare the drugs and check for differences. One of such comparisons of analgesic drugs is Norco and Oxycodone. Both drugs, Norco and Oxycodone, are Schedule II substances which simply means that their usage may make the patient or the consumer susceptible to dependency and addiction. Besides, these are narcotics that belong to the drug class opioid.

What could be the difference then? To make your decision this article provides you with basic information significant enough to cover the Norco vs Oxycodone drugs comprehensively. Similarities and differences of these opioids are covered in this article. To get an idea about the same read further.

What Are The Opioids?

Before starting with the information regarding Norco vs Oxycodone we should first understand what the opioids are. Opioids also generally known as narcotics are utilized for pain relief. Chronic, persistent, and moderate to severe pain is treated with these opioids. Our human body has opioid receptors in various body parts namely spinal cords, brain, and other ones. These receptors are proteins. These medicines having attached to the receptor protein block the signal responsible for the pain sensation and produce a relieving effect.

What Is Norco Pain Medicine?

Norco opioid is a combination of Hydrocodone Bitartrate and Acetaminophen. Hydrocodone bitrate is a salt of tartaric acid that is present and found in citrus fruits mainly. Moreover, Hydrocodone is an opioid pain reliever while acetaminophen is a pain reliever that is generally used for treating fever or maintaining body temperature.

Norco Side Effects:

Norco medication can cause some allergic reactions and side effects. These are difficulty in breathing, hives, and swelling. Vomiting, sleepiness, tiredness, headache, dizziness, lightheadedness, abdominal pain, and nausea are some common side effects of these Norco pills.

What Is The Drug Oxycodone?

Oxycodone is utilized for relieving persistent or chronic pain. It is a semi-synthetic opioid derived from thebaine which is a natural alkaloid. This alkaloid is extracted from papaver somniferum. Oxycodone is one of the medicines that are enlisted in the World Health Organization’s (WHO) essential medications list.

These pills activate μ miu opioid receptors and release a g-protein complex that acts by inhibiting the release of the neurotransmitter. Further altering the perception of the pain and eroding sensation. This is how it works and produces a calming effect in the human and gives a euphoric feeling.

Side Effects Of Oxycodone Drug:

The oxycodone side effects of this drug include abdominal pain, diarrhea, dizziness, dyspnea, fatigue, headaches, lightheadedness, loss of appetite, low blood pressure, low libido, muscle Weakness, nervousness, physical dependence, and urinary retention.

Impact Of Abusing, Norco And Oxycodone Opioids:

Opioid medicines usage is increasing multi-fold day by day due to various external pressures on the brain and accidental cases. Over two and a half million people in the United States are opioid dependent. Moreover, oxycodone abuse data shows that approximately 13 million Americans are abusing this drug for no significant purpose. This is alarming to have such data so we should be cautious and keep the pros and cons of utilizing this drug in mind while taking these.

Similarities Between Norco And Oxycodone:

Firstly, Norco and Oxycodone are opioid pain relievers that have similar working styles. They block the neurotransmitter signals that make the human body feel the sensation of pain.

Secondly, Apart from the functioning these medications also have similar drug metabolism. Increased or decreased plasma concentration. The inhibition and amplification, any kind of alteration, may cause a reduction in the efficacy of the drug. If inhibitors CYP3A4 and CYP2D6 interact this may Influence therapeutic effects adversely.

Thirdly, Short-term is the period recommended for both the medication in treatment and management of moderate to severe pain in the patients.

Difference Between Norco And Oxycodone(Norco vs Oxycodone):

As the main and active ingredients of these drugs are different, they also have some different points. These points are explained in the article below.

Norco contains acetaminophen that may result in severe skin reactions or allergies namely stevens-johnson syndrome (SJS), Toxic epidermal necrolysis(TEN), or Acute generalized exanthematous pustulosis (AGEP). These diseases as outcomes or side effects of the pill can be fatal resulting in death. Moreover, as it contains hydrocodone and acetaminophen both excreted by kidneys it is more risky to take this drug for the longer term.

Norco pills higher chance of adverse impacts on the liver because of acetaminophen combination with hydrocodone. Fatal allergies may occur that can exacerbate the health condition of the patient. Blisters and peeling off of the skin may be the consequence of this generic medicine.

High levels of serotonin may be the adverse outcome of using Norco. Although using Oxycodone may also result in serotonin syndrome the severity is higher in Norco usage. However, Pain with fever can only be managed better with Norco as it contains acetaminophen.

The risk of liver failure and adrenal insufficiency resulting in degrading its functioning may be caused by Norco usage. Oxycodone impacts the bowel movement of the patient and may cause moderately severe constipation. The risk is this adverse outcome is relatively lower in the Norco drugs.


This article is no alternate to the original and professional data mentioning the facts but it covers all the significant points one must be aware of. Since the ingredients and their effects are explained it may help you in deciding which one is right for you amongst these. If you have liver-related disease then you must not use the Norco without proper guidance and appropriate prescription.

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