Oxycodone 40 mg also known as Oxycodone Hcl Extended-Release Tablets is used in managing severe pain in some special cases. These said special cases include, the patient being above 11 years Opioid-tolerant, and must be already receiving oxycodone hydrochloride 20 mg dose on a daily basis. The pills are used for around-the-clock and long Opioid term treatment of pain.
What are the ingredients of 40 mg Oxycodone?
There are both active and inactive ingredients present in 40 mg Oxycodone.
Active Ingredient: Oxycodone Hydrochloride
Inactive Ingredients: Butylated Hydroxytoluene, hypromellose, polyethylene, magnesium stearate, titanium dioxide, polysorbate, and ferric oxide yellow.
What does Oxycodone 40 mg look like?
The pills are easily recognizable in the form of film-coated ER tablets. They are available in the market in the form of round, bi-convex tablets tablets painted in yellow. It has OP printed on one side and 80 on the other.
How does Oxycodone 40 work?
Oxycodone 40 mg works by binding itself to opioid receptors, especially the mu receptor. Due to this action, the chemicals initiating analgesia are released that travel along the brain and spinal cord.
Side Effects of Using Oxycodone 40 mg:
Every medicine is most likely to have side effects. Some of the side effects are as mentioned below:
- Sleep Apnea
- Dry mouth
- Loss of appetite
- Abdominal pain
- Unusual tiredness
- Weight loss
- Severe dizziness
Warning and Precautions While using Oxycodone 40 mg:
Addiction and Misuse:
40 mg pills are a higher extended dose of Oxycodone. Oxycodone is an opioid that comes with the risk of being abused and causes addiction. This risk increases if the patient has a history of drug/alcohol abuse or addiction. Such patients are more likely to get addicted and have a constant risk of getting into depression.
Life-threatening Respiratory Depression is observed in patients even after the prescribed dose of 40 mg Oxycodone. This is most likely to happen in the initial stage of treatment (24-72 hours). That is the primary reason for excessive monitoring of patients in the first 72 hours. Along with that, the patient needs to be careful when/if the dosage is increased in the late stages of treatment.
Respiratory Depression can be managed through:
- Using Opioid Antagonists
- Carbon dioxide Retention
Life-Threatening Neonatal Opioid Withdrawal Syndrome(NOWS):
This is likely to happen in a pregnant woman if she continues to use Oxycodone 40 mg even during the last stages of pregnancy. This syndrome not only poses a severe risk(including death) for the mother but can also cause lasting side effects in a newborn.
The common signs for NOWS include:
Other significant risks of using Oxycodone 40 mg include:
- Patients with Chronic Pulmonary Disease and Debilitated Patients should be extremely careful while using a 40 mg pill of Oxycodone as they are more likely to suffer from Respiratory Depression which can easily lead to death.
- These are also chances of Adrenal Insufficiency in patients. This is likely to happen after one month of use of Oxycodone. The symptoms of Adrenal Insufficiency include vomiting, anorexia, nausea, dizziness, fatigue, weakness, and low blood pressure. In such cases, Oxycodone 40 treatment is immediately stopped and replaced with corticosteroid treatment until the treatment wears off.
- While using this medication, there is always a chance of conditions of hypotension especially in patients with syncope.
- Oxycodone pills of 40 mg may reduce respiratory drive in patients with brain tumors, head injury, increased intracranial pressure, or impaired consciousness. Just make sure to inform your doctor if you undergo any of the mentioned conditions.
Drug Interaction of Oxycodone 40:
- Oxycodone 40 mg when taken with P450 3A4 Inhibitors can lead to adverse side effects including fatal respiratory depression as these medicines increase the plasma concentration of Oxycodone. Some examples of P450 3A4 Inhibitors include erythromycin, ketoconazole, ritonavir, etc.
- Use of CNS Depressants with 40 mg pills can lead to side effects such as Profound sedation, coma, respiratory depression, and in the worst cases death. The reactive CNS Depressants include anxiolytics, tranquilizers, general anesthetics, non-benzodiazepine sedatives, hypnotics, muscle relaxants, and antipsychotics.
- Do not use serotonergic drugs such as triptans, trazodone, SSRIs, SNRIs, TCAs, 5-HT3 receptor antagonists, mirtazapine, tramadol, metaxalone, cyclobenzaprine, etc. with the medication.
- It is advised not to take Monoamine Oxidase Inhibitors such as phenelzine, linezolid, and tranylcypromine with Oxycodone 40 mg pills.
Other medications that react with Oxycodone 40mg:
- Anticholinergic Drugs
Overdose of 40 mg pills of Oxycodone :
When the patient knowingly or unknowingly takes the medication in more than the prescribed amount, it often leads to various kinds of reactions in the body. These symptoms of overdose can be minor as well as major depending on how the body reacts to the medicines.
Some overdose symptoms of 40 mg pills include:
- Pulmonary Edema
- Airway Obstruction
- Atypical snoring
Frequently Asked Questions
Q.1. Is Oxycodone 40 mg ER the same as Oxycontin 40mg?
No, both medicines are used in different conditions despite being majorly the same in composition. Oxycodone 40 mg ER is used to treat pain mainly due to surgery or major accidents whereas Oxycontin 40mg is used for the treatment of long-term pain management.
Q.2. If I take oxycodone 40mg a day for a month, how long will it stay in my urine if I stop?
Oxycodone 40 mg will stay up to 4 days in an otherwise fully functional adult after the last dose of the pill.