Fladrafinil Vs Modafinil (Best Medicines To Treat ADHD)

Fladrafinil Vs Modafinil

The world has a matchless pace of economies that demands unmatchable skill and focus from candidates in order to excel and sustain. So the drugs that promise better focus, and concentration for a longer span, and cognitive capabilities enhancers have a significant portion in booming industries. To find a better supplementary dose, People compare modafinil, termed and popular as the world’s first safest smart, against Fladrafinil for its better ‘wakefulness’ qualities.

In this blog, we will be touching on all the important aspects of Fladrafinil vs Modafinil that make them one of the best choices for ADHD treatment.

What Are Fladrafinil And Modafinil?

Within significantly less time these drugs became popular among students and sports people due to their strong effects lasting for more time relative to other similar drugs. Both of these drugs have been enlisted in the “smart drugs” list recognized for their cognitive enhancement properties, besides wakefulness.

Fladrafinil and Modafinil are Eugeroic(class of wakefulness-promoting compounds) medicines. Having nootropic effects, these medicines find their application in diseases related to sleepiness, even in the daytime. Fladrafinil contains fluoride molecules in addition (fluoride molecules help in the absorption of drugs efficiently and improve the potency and bioavailability of the medicine) modafinil is a nootropic drug and works as a eugeroic as well. The major difference between their composition is fluoride.


Fladrafinil, CRL-40941 is a eugeroic, that derives its composition from adrafinil(1970s medicine for narcolepsy). It functions by preventing the breakdown of dopamine(which is a neurotransmitter related to emotional responses learning and attention) ultimately resulting in high dopamine experiences that make the learning task easier and less bothering. Hence, Fladrafinil has the potential for learning and motivation enhancement

Few studies related to Fladrafinil, especially in 2010, although it is not a well-researched drug, found this medicine does help in mental performance, clarity of thought, and ability to plan even a monotask.


Initially approved for narcolepsy by the FDA is now gaining popularity amongst healthy people who are consuming it to enhance their creativity and problem-solving abilities. It also does help them to be more decisive as concluded by Harvard and Oxford University researchers. It is sold under the trade name of Provigil.

Modafinil medicine is used to promote wakefulness in a person taking it by impacting catecholamines which are neurotransmitting hormones. It is popular amongst medical experts and patients of sleep-related diseases and problems due to its composition of nonamphetamine agents (these are non-psychostimulants having less to extremely low negative effects on the psyche of patients). Enhanced attention span and wakefulness are its outcomes, by virtue of which, it has gained popularity.

Benefits And Uses Of Fladrafinil And Modafinil:

Apart from cognitive function improvement and motivation-related issues, these medicines benefit senior/older people as age progresses. The eugerioc property of these drugs is making it quite popular in today’s fast fast-moving economic society making people exhausted within no time.

Fladrafinil Benefits and Uses:

Mood-altering effects of Fladrafinil, like caffeine, make it beneficial for wakefulness during daytime/work time and could increase motivation. This drug acts by inhibiting adenosine receptors and significantly lightens up the mood helping in depression alleviation as well.

The cognitive function of the brain is enhanced by amplifying the adenosine (chemical messenger) function. In fact, some studies suggested that Fladrafinil is relatively strong amongst other eugeroic drugs.

Thus, Fladrafinil could be beneficial in the following spheres.

  • It enhances the learning capacity of a person.
  • By calming the mind it reduces aggressiveness.
  • Memory creation is another benefit of using these medicines.
  • Recall and retention power could be improved.

Modafinil Benefits and Uses:

Modafinil slows down the GABA inhibition rate. To make it simpler, let us explain that GABA (stands for gamma-aminobutyric acid) is an acid that functions as a neurotransmitter in the human brain. t also activates the glutamatergic circuit (which is responsible for processing sensory information). These make Modafinil medicine useful in fighting narcolepsy diseases

Uses of modafinil include:

  • Sleeping disorders (work shift sleep disorder) are treated.
  • It works as a remedy for Excessive daytime sleepiness (EDS).
  • Helpful in curing Obstructive sleep apnea.
  • Majorly prescribed by medical practitioners for Narcolepsy.

Fladrafinil Vs Modafinil: Side Effects Comparison

When it comes to the side effects of Fladrafinil and Modafinil these are similar to other drugs. Every drug has the potential to have side effects. Although no study has shown any side effects related to Fladrafinil as of now this medicine has not been thoroughly researched.

Since these medicines influence the psyche by changing chemical influences on the brain, taking these medicines for a long span of time can have an impact on the sleep cycle. These are not severe but common side effects. Since their functioning directly impacts dopamine(by its breakdown prevention property), the patient is prone to addiction because of its pleasing effect on the mind.

Some general potential side effects of these medicines are given below.

Fladrafinil side effects:

  • Anxiogenic ( causing anxiety) tendency
  • Insomnia and headaches
  • Restlessness
  • Noticeable urine odor

Modafinil side effects:

  • Long-term usage results in insomnia in patients and at the same time anxiety occurrence would be common.
  • Feeling nauseous and less frequent headaches could be observed.
  • appetite can be reduced after having continuous doses.
  • Moderate addiction is common, in the long term.

Important Note:

Some groups of people are more vulnerable than usual and healthy people. These are geriatrics, pediatrics, pregnant, and renal patients. They can have severe side effects on health.


Although there are some results showing Fladrafinil in more light and no moderate to severe side effects of the medicine, we can not overlook the fact that it is not well-researched. Hence, Fladrafinil is not recommended for everyone. Medical expertise in prescription is advised. While modafinil is amongst the most popular tried and tested drugs certified by the Federal Drug Administration, United States.

In final words, we would say it is up to your medical practitioner and your discretion to decide about the use of either of the drugs.

Read More:

Best ADHD Medication For Adults: The Perfect All-In-One Guide

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