If you are suffering from several different diseases and taking multiple medications, then it is important to know their drug interactions. Exactly when you are using Fluconazole and Oxycodone, you should also aware of its drug interactions. Because they are not used for same purpose and not affects same area of your body. So it is important to know how their combination merits or demerits your overall health. Therefore, we provided a clear knowledge of “Drug Interactions Between Fluconazole and Oxycodone” and how to avoid their negative impacts briefly in this article.
Pharmacokinetic Drug Interactions of Fluconazole and Oxycodone
It is important to know the interactions between the two pills to prevent harmful effects in the patient suffering from severe pain or mycosis. To get the positive effects and avoid negative interactions most important thing is to be adjusting the dose properly. So it is important to know their combined effects in detail. Let’s discuss the reason behind it, how to cure and how to prevent the drug interactions in below. Initially, let’s know about the pills and how they are useful to us.
What is Fluconazole and it’s Working Mechanism?
Fluconazole belongs to a class of azole antifungals used for the treatment of fungal infections. Infections that are caused by fungi and yeasts might be cured by Fluconazole. It is commonly available in the form of tablets/capsules, liquid, and intravenous form. The Fluconazole pill main intention is to stop the growth of Fungi by disrupting their cell membrane. It blocks lanosterol 14-alpha-demethylase, which is an enzyme that is needed by cell membrane to build their cell membrane. As a result growth of Fungi is stops and it dies permanently.
What is Oxycodone and it’s Working Mechanism?
Oxycodone is an opioid that is generally used for managing pain, in chronic conditions. It has the active component, Oxycodone Hydrochloride that affects central nervous system to inhibit the perception of pain. Oxycodone doesn’t affect the source of pain; it only alters the way of feelings pain. It is available in oral form and sometimes prescribed by the doctors for ingestion in severe cases. It is also available in combined forms like Percocet, OxyContin, and Roxicodone.
After taking the Oxycodone pill orally, it mixes with blood and binds to the mu-opioid receptors. This binding results blocking of pain signals. It blocks the transmission of pain signals and alters the perception of pain into relaxation. Oxycodone also increases level of dopamine which leads to feelings of pleasure and relaxation.
How Fluconazole Affects Oxycodone?
CYP3A4 is an enzyme that metabolizes Oxycodone in the liver. Fluconazole blocks the the enzyme CYP3A4 which regulates the metabolism of Oxycodone. You can say that Fluconazole is a CYP3A4 inhibitor, for which when you take Fluconazole, Oxycodone will breaks slowly and it will stay longer in your system. This process results increase in oxycodone level in the blood. Increase in Oxycodone level in the blood specifies that it will cause a stronger effect due to the higher concentration.
Increase in Oxycodone level can cause some positive effects like, quick relief from pain and more relaxation. But it can also cause serious side effects due to the analgesic effects.
Potential Risks Associated to Drug Interactions
When you combine the drug Oxycodone and Fluconazole it will cause excessive sedation, dizziness, confusion, low blood pressure, respiratory depression, and increased risk of overdose symptoms to the patient. The risks for older and younger people is more due to their weaker immune system. In some cases it will appear death like situation when the doses are more stronger.
Signs After Interacting Oxycodone and Fluconazole
If you are taking these two drugs combinely without the knowledge of it’s effects, then you will feel this symptoms as soon as it reacts. Slow breathing, extreme drowsiness, bluish lips, irritation, or confusion might be seen in short period of time to the patient.
Whenever you notices these symptoms in you or in your loved ones immidietely go for a medical check up. Before it worsen take appropriate precautions to be cure. The best suggestion is to use the pill after knowing all its composition and it’s allergic reactions to you. You should tell your doctor about currently taking medications and medical history before starting Oxycodone or Fluconazole.
Frequently Asked Questions(FAQs)
Can You Take Oxycodone And Fluconazole After An Accident?
If you have any fungal infections before and you currently have an accident then you can take these combinations but with a proper medical supervision. Because it’s drug interactions can cause serious side effects to the patient. You should consult an experienced physician first and then took your medication. Fluconazole will cause delay in breaking down of Oxycodone and other medication, therefore you should ask your physician to take it.
Is Oxycodone And Fluconazole Safe For Pregnant Women?
Both oxycodone and fluconazole carries risks in pregnant women, to be used without knowing the post effects. But in serious cases you can take it only after asking your gynecologist. Oxycodone is used for pain relief and Fluconazole for fungal infections. If you need to take any of these or want to take combinely then it can cause the chances of miscarriage and some life threatning issues. So ask your doctor, before taking anything.
Conclusion
For safe and effective treatment most important thing is to knowing the interactions of medicines, specially when you going through more than one disease. Fluconazole and oxycodone are used for pain relief and another one for fungal infection as you know in the above. Both can be effective or harmful at the same time that depend on amount of doses and current health condition. Whenevr you take these combination must take a suggestion from a healthcare provider and follow the guidance for recovering safely.