Can Oxycodone Cause Swollen Feet?

Short answer: Oxycodone can occasionally cause swelling (peripheral edema) in the feet and ankles, but it is not among its most common effects. More often, swelling in someone taking oxycodone comes from the reason they need the drug (an injury, surgery or immobility), from other medicines taken alongside it (NSAIDs, gabapentin, pregabalin, amlodipine, steroids), or …