Oxycodone and Electrolyte Imbalance
Short answer: Oxycodone does not usually upset your electrolytes on its own, but it can contribute in several ways: vomiting, diarrhea from withdrawal or laxatives, reduced eating and drinking, rare hormone effects such as SIADH (which lowers sodium), and, with long-term use, adrenal insufficiency. Persistent weakness, cramps, confusion, a racing or irregular heartbeat, or severe …