Oxycodone and Antidepressants: Risks and Warning Signs

Short answer: Oxycodone and antidepressants are often prescribed to the same person, and many people use them together safely under supervision. The main dangers are serotonin syndrome (a rare but serious reaction to too much serotonin activity), extra sedation and, with one older class of antidepressants called MAOIs, a firm “do not combine without specialist …