Can Oxycodone Cause Acid Reflux?

Yes, oxycodone can cause acid reflux. It doesn’t make your stomach produce more acid. Instead, it slows the movement of food out of the stomach and changes how the food pipe (esophagus) contracts, giving acid more opportunity to travel upwards. For some people this means occasional heartburn after meals. For others, especially those who already …

Oxycodone and GERD: What Patients With Chronic Reflux Need to Know

At a glance: Gastroesophageal reflux disease (GERD) is a chronic condition, and oxycodone is a powerful opioid that acts on receptors throughout the digestive tract. When the two meet, the concerns go beyond an occasional bout of heartburn. They include how the esophagus moves, how quickly the stomach empties, how reflux medications fit into your …