Oxycodone and Frequent Night Sweats

Short answer: Yes, oxycodone can cause night sweats, and sweating is one of its recognized side effects. But when drenching sweats happen often, the opioid is only one suspect on a list. Others include dose-timing gaps that trigger mini-withdrawal at night, histamine release, drug combinations (especially antidepressants), low blood sugar, infection, hormone changes, sleep apnea …