Oxycodone and Anxiety Medications: Safety Risks Explained

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Short answer: Oxycodone and anxiety medications are a high-caution pairing. Benzodiazepines such as Xanax, Ativan, Klonopin and Valium carry an FDA boxed warning when taken with opioids, because the combination can cause profound sedation, slowed or stopped breathing, coma and death. Other anxiety treatments, including gabapentin, hydroxyzine, sleep drugs, SSRIs and buspirone, range from “needs …

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Oxycodone and Antidepressants: Risks and Warning Signs

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Short answer: Oxycodone and antidepressants are often prescribed to the same person, and many people use them together safely under supervision. The main dangers are serotonin syndrome (a rare but serious reaction to too much serotonin activity), extra sedation and, with one older class of antidepressants called MAOIs, a firm “do not combine without specialist …

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